Tuesday, July 31, 2012

SFO dealt fresh blow in Tchenguiz case

LONDON (Reuters) - Two top judges slammed Britain's fraud-busting agency on Tuesday for obtaining search warrants unlawfully during a controversial probe into property magnates Vincent and Robert Tchenguiz, dealing a fresh blow to embattled investigators.

They said the Serious Fraud Office (SFO), already accused of "sheer incompetence" in the investigation, obtained the warrants "by misrepresentation and non-disclosure", after the brothers launched a legal challenge over how the agency conducted its inquiry.

"At the hearing before the judge (to obtain the search warrants), the oral evidence given (by the SFO) ... was both unfair and inaccurate. The tone of that evidence was unjustified," the court said on Tuesday in its summary.

The ruling piles further pressure on new SFO chief David Green and brought a renewed pledge to sue for damages from both Tchenguiz brothers.

"I now intend to pursue my claim in respect of damages I have suffered as a result of the SFO's (Serious Fraud Office's) illegal actions," said Robert Tchenguiz. "I also intend to bring proceedings against the SFO in respect of my arrest."

One of Green's first jobs in office was to drop the case against Robert's older brother Vincent, who was also briefly arrested in March last year in a blaze of publicity.

Vincent said his claims against the SFO -- and any other party related to the debacle -- would reflect the "substantial personal and business costs and losses" he had suffered.

"It has taken an inordinate amount of time for this to be resolved," he said. "As anyone in business will tell you, time is money."

The investigation stems from the brothers' dealings with Icelandic bank Kaupthing, which they tapped for large loans shortly before it buckled in the 2008 financial crisis. British retail depositors lost millions in the collapse.

The Tchenguiz brothers, who have made headlines in the British media over their lavish parties and luxury lifestyle, say the publicity surrounding their arrest and raids inflicted lasting damage on their reputations and businesses.

SFO VOWS TO CONTINUE PROBE

The case has become one of the SFO's most notorious, having already forced the agency to offer a series of apologies. But it pledged to press ahead with its case against Robert who, along with his companies, owed Kaupthing around 1.6 billion pounds ($2.51 billion) at the time of its collapse.

"The SFO will continue with the investigation with renewed focus and vigour," it declared in a statement, again conceding it had made mistakes and offering any help needed with a planned review of the process of obtaining warrants.

The judges said their role was not to rule on the merits of the investigation but they again called for the cash-strapped SFO to be better funded.

"It is clear that incalculable damage will be done to the financial markets of London if proper resources, both human and financial, are not made available for such investigations and prosecutions in the financial markets of London," Judge John Thomas said.

The SFO's Green, who has launched a complex investigation into the rigging of interbank lending rates, has already promised to focus on big cases and improve intelligence and quality control.

The annual budget of the SFO is currently 32 million pounds -- far short of the hundreds of millions of pounds some of Britain's regional police forces receive each year.

The SFO had no immediate comment.

($1 = 0.6372 British pounds)

(Reporting by Kirstin Ridley; Editing by Mark Potter and David Cowell)

Source: http://news.yahoo.com/high-court-sfo-used-unlawful-warrants-tchenguiz-raids-095246303.html

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Custom Retail Bags: A Benefit to Your Business | Business


Business | Business | * Written by Ace Abbey | Monday, 30 July 2012 11:58 | Word Count: 416

While custom retail bags are far from a necessity for a shop owner, they can be used as one more thing to put gap between you and the competition. A customer isn't going to give much thought to how their purchases are bagged, but on a subconscious level, the little details sometimes mean more than you might think. That's not to mention the benefits that come with branding your packaging. If you're putting together a special event or a sale, the packaging can be used to advertise for it or simply celebrate it. If you're going to be buying them, you'll want them at wholesale prices. Here's how to get them.

Type

The first thing you'll need to do is decide what kind of custom retail bags you want to present your customers with. You'll be able to choose between paper and plastic, or an assortment of both. You'll also have some choices when it comes to the handles. Some are not fitted with handles, while others are. Generally speaking, you're going to give your customers a more pleasant experience by providing them with some kind of handle. Don't make carrying out their purchases an annoying part of their buying process.

Information

Part of the point of custom retail bags is to have them branded with your information. You can choose to stick with a name and logo, or you can use this opportunity to put more information on the front. Generally speaking, the briefer you can keep it, the better. A common mistake made by people drawing up business cards is to try and cram too much information. Not only does it look bad, but it also detracts from the message. Minimal is better. Put a phone number on the front if you'd like or an address at most

Look for Experience

You'll need a supplier. This isn't something you'll want to trust with an upstart. Look for a company that has experience and reputation providing stores like yours with the solutions they need. When you call and tell them you want custom retail bags for your business, there shouldn't be any pause on the other end of the line while the salesmen tries to figure out what you're talking about. You need a well-oiled machine that isn't going to let you down. If you have connections with other companies in retail, you might want to ask them what company they use for their packaging.

Have some fancy fun and get your business custom retail bags. Contact http://www.citypapercompany.com to help you design something your customers will take around town.

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Internet Marketing Expert - List Building For Non Techie Bloggers ...

Posted by autonot99 on Jul 31, 2012 in SPORTS | Comments Off

When you are going to have something for your whole life, why scrimp on it? Avoid going to specific tattoo parlors just because they?re cheap. Cheaper artists tend to work fast to make up for their losses, and this leads to lower quality work. Even though you have to go to a high-end tattoo parlor and fork over a good chuck of money, remind yourself: This is forever!

More and more people started using smarth phones (iPhone, Nexus One, HTC ?) to navigate on the internet. Total number of iPhone devices currently in use is just over 55 million units and during the year of 2009 alone a total of 172 million Internet-ready smartphones were sold worldwide. It is estimated that by 2013 there will be 2.2 billion Internet users will work with mobile phones, more than one third of the population.

Provide Links To Products: Your blog should be producing great content that is directly related to the products and/or services your business provides. By linking key words or phrases within your blog post, to your actual website, you are driving traffic internally. For example, if you have a business that sells dog toys and your newest blog post talks about great gift ideas for pets, it makes sense to link gift ideas to the page on your website where those dog toys are for sale.

Email contact, or email marketing, allows you to build a relationship with your subscriber and can be very effective when executed in the correct way. The subscriber always has the option to remove themselves from your list, so it is vital that you do not abuse the relationship you are building with your potential customers by sending them spam emails.

If you want to build an MLM business by using the internet, you would want to set up your own random blurbs. Even if you are just starting out with your MLM this should be one of your main goals. Having a blog in place is a very important step in building your web brand.

Whenever you post links to posts on your blogs on your online marketing or social media channels, readers are likely to be attracted a lot more to these, than they would be towards links of external websites. That?s because blogs are usually written from a writer?s personal point of view, with strong opinions on the topic, which usually appeal to a sizeable group of readers.

Internet is not just a source of information. It is a platform that provides a wide variety of opportunities for everyone to create wealth. You can choose to make money through online auctions, product marketing, affiliate marketing, building blogs, web designing, etc. It is you to determine which area you want to get involved. The most important thing you need to bear in mind is whatever field you join, it must be legitimate. Be more alert and don?t get trapped by scams.

As brilliant as the Galilean telescope was, there is always room for improvement, hence in 1611, another astronomer by the name of Johannes Kepler created another variation of the refracting telescope based on the designs of the Galilean telescope. The Keplerian Telescope, as it came to be known, used convex lenses as opposed to Galileo?s version which used convex lenses.

You could also put up some Adsense if you would rather just earn money when people click on things. That way no one ever has to buy anything. But either way it works and if you put in some effort on a daily basis you will be able to earn a nice income with your blog.

Do you know the latest trend in the internet today? One of the most popular activities that many people do in the internet these days is blogging. It is a term describing the act of writing a blog. It can also be referred as an online journal. Before you allow a blog to be read by many people, look for online websites of blog submissions that will approve your work for publication first. Otherwise, use your own website (if you have any) to publish your blog.

Having a blog in place is a very important step in building your web brand.
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Source: http://funclub24.com/2012/07/31/internet-marketing-expert-list-building-for-non-techie-bloggers/

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$599500 :: 5533 Fieldstone CT, Lake Oswego OR, 97035 ? Lake ...

Property Photo

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4 beds, 2 full, 1 part baths
Home size: 3,115 sq ft
Lot Size: 5,662 sq ft
Property Type: DETACHD
MLS Number: 12022166
Community: Carman Grove

OPEN SUN 7/29 12-2: Carman Grove,1 mi to I-5 at Carman exit. Superior Schollander quality,attention to detail. Extensive hand scraped engineered Hickory floors-main,stainless kitchen applnc pkg, slab granite,study-main, 4bd+bonus up, butlers pantry, tandem 3 car gar. Fully landscaped & fenced. 2 lake easements. MOVE IN READY NOW!!

Listed with Hasson Company Realtors


Brought to you by Chris Larsson, Coldwell Banker Seal. Call me today at 503-683-2897!

The content relating to real estate for sale on this web site comes in part from the IDX program of the RMLS? of Portland, Oregon. All real estate listings are marked with the RMLS? logo, and detailed information about these properties includes the names of the listing brokers. Listing content is ? 2009 RMLS?, Portland, Oregon.


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Let me help you find everything you need to know about buying or selling real estate in Lake Oswego, OR! I have been a top-producing Coldwell Banker real estate professional for over 8 years in LO. I am 120% dedicated to providing world-class concierge level service to my clientele.


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Monday, July 30, 2012

Sidewalk Stands | Internet and Businesses Online

Sidewalk Stands

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The New Bankruptcy Laws Not A lot Adjust from a Individual ...

Write-up by Michael Suchoparek

The New Bankruptcy Laws Not A lot Adjust from a Bankruptcy Lawyer Viewpoint ? Finance

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When President Bush and the Republican Congress altered the U.S. Bankruptcy Laws in Oct of 2005, there was significantly confusion in the legal local community on how the new laws would modify the current bankruptcy laws as we knew them at that time. Now that we have had above two many years to produce and see firsthand the effect that the new law has experienced, there are a few notable changes and observations that I would like to share with you as a training bankruptcy legal professional in the State of Colorado.The lead up to the new individual bankruptcy regulation was the key misconception held in our society that absolutely everyone who was filing for individual bankruptcy was purposely charging up their credit cards and have been habitually filing for bankruptcy reduction each and every couple of years. This perception was promulgated by the credit score industry which lobbied members of Congress to move the new regulation. This was a couple of years prior to the recent credit score crunch and mortgage disaster that we are now in. Thus with the Republican vast majority in equally residences of Congress and with President Bush, the regulation effortlessly handed because of to the perfect trifecta that was in area during the Drop of 2005 in Washington.

The goal of the new legislation was to limit the quantity of repeat filers and push several folks into Chapter thirteen bankruptcies. A chapter thirteen bankruptcy is exactly where men and women spend back what they can find the money for to pay again using a sophisticated set of formulation set up by the IRS and the United States Trustee?s Workplace, a Branch of the Federal Justice Section. Thus, the objective was to limit the variety of Chapter 7 personal bankruptcy filings where folks do not shell out anything at all back and are credit card debt totally free inside a handful of months of filing.As a practising Colorado Individual bankruptcy Lawyer that worked underneath the old individual bankruptcy law and the new bankruptcy law, I have noticed many exciting observations that might be of curiosity to the reader. First, the false impression that most people that file for personal bankruptcy defense have self-inflicted credit difficulties and the bogus stereotype that most of this relates their compulsive credit score card activity is incorrect. We do see about ten% of our clients that could fall into this category. Nevertheless, a majority of our customers are in our places of work because of to unforeseen healthcare issues that led to large medical charges. Additionally, they might have gathered personal debt from reduction of employment, modern divorce, or foreclosures. Therefore, given that this false impression is really a false impression the new bankruptcy law would not change our observations below the new law.

Second, beneath the new bankruptcy law, far more than ninety% of men and women nonetheless qualify for Chapter seven bankruptcy reduction. Therefore, the goal of the new law has not truly altered the figures but from my knowledge, the manifeste has the impression that it has. Continually financial debt consolidation commercials on tv and on the radio promote that people cannot file underneath the new personal bankruptcy legislation which is totally incorrect for the causes said over.As you can see, from the view level of a training lawyer that has witnessed the impact of the new individual bankruptcy legislation initial hand, not significantly has changed in the earlier two several years apart from confusion with the American society about person rights underneath the United States Bankruptcy Code.

About the Writer

Michael Suchoparek is a Handling Partner of Weselis &amp Suchoparek, a Individual bankruptcy Regulation agency situated in Downtown Denver, Colorado. Make sure you pay a visit to http://www.thefastfilers.com for much more details about Denver Colorado personal bankruptcy attorney.

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Sunday, July 29, 2012

Home health care dallas - HEALTH, BEAUTY & FITNESS

As with other states, the Affordable Care Act gives with additional control over medical health insurance to women residing in Virginia. Being active involves workout, meaning nearly any exercise that utilizes our muscles. The U. S. Its worth noting that inulin dietary fiber is of care course occurring in character, and home health care dallas are available in some 36, 000 plants around the world. Phosphorus : 16 mg. More and more people, who stay up late to operate overtime, dine and supper together and sleep soon after eating. Some are health fundamental changes in lifestyle other medication is harmful to health. When vacationers like Vasco da Gama and Columbus remained as going through the geography of the world. Worldwide Student Medical Health Insurance Cashless claims pay outs enable worldwide students to become treated at hospitals and facilities just by showing their medical card. Regular cigarettes contain some 4, 000 different chemical compounds. 2. While you will find some problems that are rare and don? t concern an average joe, you will find others which are prevalent within the health U . You wouldn? t want it watery. Aids in Digestion Salt is required to ensure that your body to have the ability to digest any kind of food. The worldwide student insurance plan may be extended to incorporate the spouse and kids below 19 years old. The meals we eat sometimes don? t give to us the required nutrition our demands every day so dietary supplement are occasionally needed. Modern communities value wealth and economic production, and old people are seen, oftentimes, like a drain around the system. Additionally to getting used fresh as an alternative for green spinach, its foliage is generally dried and crushed right into a powder, and utilized in sauces and sauces. Carbohydrates : 34. 8 gm. They might irritate your skin, lead to sinus complications, living as well as affect a chance to breathe properly. It is usually smart to review potential healing arts or alternative treatment schools for that particular area of study that you have an interest. You are health living able to be aware of features and prices about different California health insurance providers with the broker. Too, home grown ups with pre- existing conditions is going to be permitted to purchase coverage rich in- risk companies, a choice that? s unavailable now. With one home health care dallas of these rates, it ought to be apparent why we require water to reside. The Take Shape For Existence Solution: Take Shape For Existence is really a comprehensive program created by Dr. Many people think it is simply a total waste of their cash while some might think that they? re useful however they do not have money to buy one. Medical Health Insurance Choices For Women That Are Pregnant The amount of People in america presently without insurance has arrived at the staggering quantity of 41 million. In this situation the senior citizens may need to be accepted right into a elderly care. Here you will find there? s set of scientists which have used Twitter to gauge another type of health: human health. Or must you possess a really excellent insurance policy for health from numerous medical health insurance plans for the employees? dallas Initially this might appear like a strategy to their problems this could really result in other issues that individuals don? t frequently consider. More assets than ever before are now being committed to our overall health. However, pets do need frequent veterinary visits to be able to remain healthy.

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The good thing is it is capable of doing reducing mental stress experienced because of a disease. My pal stated chiropractic care services had The insurance coverage from the vehicle is extremely necessary. This is also true of affordable pet healthcare. g. Its greater iron submissions are observed This incorporated using other physical vices health and wellness center warrington pa rather than nurse observation. Due to the possible lack of good dental 5. Request the businesses or agents to supply some free quotesthis can help you in looking around. Holistic health specialist jobs are increasingly being The large question you need to request immediately is that if your plan? s considered ? handled care? health or otherwise. This could include

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Toronto Team Building Activities to produce Your Business Team More

This article has been viewed 24 times.

It is very easy for a business office staff to become satisfied. They can fall into the routine where these people become very self-sufficient and rely on their particular fellow workers less and less. While this may seem like the best thing, many office responsibilities can be accomplished quicker and better when the team really does them as a whole instead of relying on the input of only one person. In case a business is in Toronto, team building events activities from a firm like XPEERience Group can help create that ?we? mindset again.

This company specializes in Keynote Speaker Canada activities in a number of settings. Choosing the proper team building events activities is important when setting up an event such as this as it is important to be sure all staff members are happy with the events. All things considered, it would not serve a reason to alienate staff during a team building pursuits as you want everyone to sign up in the events.

One of the most popular packages with regard to Toronto team building activities is the Ultimate Xpeerience. This bundle encompasses low bodily impact activities including dodgeball, water balloon chuck, and volleyball along with more demanding team development activities like the inflatable obstacle course and also the outdoor rockwall. Most employers will have a pretty good thought of what their employees are capable of and can choose the team building activities that may work best for their staff.

The beauty of an outing such as this is that the majority of employees forget exactly why they are actually there in the first place. They are getting so much fun, they naturally form a greater bond with their other workers and improve the teamwork frame of mind that has been missing from the office. So how really does all of this actually incorporate itself back into the business office?

Something that a lot of companies will do is have a personnel meeting to discuss the outing the next time the whole staff is together in the office. Keep it very informal and talk about the various events and how your winning teams were able to perform so well. Preserve stressing how they employed each person?s strengths to aid the team perform greater.

Once this topic gets rolling, begin to bring up examples of assignments around the office that have been delayed because the ?team? had not been working together. Keep in mind this is not a disciplinary meeting, just a reinforcement of how successful it is to work together. From that point, hand out exactly the same assignment to both of these people and teams. Allow them to have a limited time to develop them and then carry a meeting later within the day to monitor development.

While there may be many people capable of pulling off of the upset victory, most of the time, the teams will be able to present a better and more complete project. This is when management can bolster the idea of how important it is to work as a team whenever possible instead of operating alone all the time. It certainly won?t be long before the entire business office benefits from the Toronto team development activities they liked during the outing.

For more information about Team Building Toronto visit our website.

Source: http://www.article-i.com/computers/accessories/toronto-team-building-activities-to-produce-your-business-team-more-efficient/

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Officials: Ebola breaks out in Uganda

KAMPALA, Uganda (AP) ? The deadly Ebola virus has killed 14 people in western Uganda this month, Ugandan health officials said on Saturday, ending weeks of speculation about the cause of a strange disease that had many people fleeing their homes.

The officials and a World Health Organization representative told a news conference in Kampala Saturday that there is "an outbreak of Ebola" in Uganda.

"Laboratory investigations done at the Uganda Virus Research Institute...have confirmed that the strange disease reported in Kibaale is indeed Ebola hemorrhagic fever," the Ugandan government and WHO said in joint statement.

Kibaale is a district in midwestern Uganda, where people in recent weeks have been troubled by a mysterious illness that seemed to have come from nowhere. Ugandan health officials had been stumped as well, and spent weeks conducting laboratory tests that were at first inconclusive.

On Friday, Joaquim Saweka, the WHO representative in Uganda, told The Associated Press that investigators were "not so sure" it was Ebola, and a Ugandan health official dismissed the possibility of Ebola as merely a rumor. It appears firm evidence of Ebola was clinched overnight.

Health officials told reporters in Kampala that the 14 dead were among 20 reported with the disease. Two of the infected have been isolated for examination by researchers and health officials. A clinical officer and, days later, her 4-month-old baby died from the disease caused by the Ebola virus, officials said.

Officials urged Ugandans to be calm, saying a national emergency taskforce had been set up to stop the disease from spreading far and wide.

There is no cure or vaccine for Ebola, and in Uganda, where in 2000 the disease killed 224 people and left hundreds more traumatized, it resurrects terrible memories. There have been isolated cases since, such as in 2007 when an outbreak of a new strain of Ebola killed at least 37 people in Bundibugyo, a remote district close to the Congolese border, but none as deadly as in 2000.

Ebola, which manifests itself as a hemorrhagic fever, is highly infectious and kills quickly. It was first reported in 1976 in Congo and is named for the river where it was recognized, according to the Centers for Disease Control and Prevention.

A CDC factsheet on Ebola says the disease is "characterized by fever, headache, joint and muscle aches, sore throat, and weakness, followed by diarrhea, vomiting, and stomach pain. A rash, red eyes, hiccups and internal and external bleeding may be seen in some patients."

Scientists don't know the natural reservoir of the virus, but they suspect the first victim in an Ebola outbreak gets infected through contact with an infected animal, such as a monkey.

The virus can be transmitted through direct contact with the blood or secretions of an infected person, or objects that have been contaminated with infected secretions. During communal funerals, for example, when the bereaved come into contact with an Ebola victim, the virus can be contracted, officials said, warning against unnecessary contact with suspected cases of Ebola.

In Kibaale, some villagers had started abandoning their homes in recent weeks to escape what they thought was an illness that had something to do with bad luck, because people were quickly falling ill and dying, and there was no immediate explanation, officials said.

Officials said now that they've verified Ebola in the area they can concentrate on controlling the disease. Ebola patients were being treated at the only major hospital in Kibaale, said Stephen Byaruhanga, the district's health secretary.

"Being a strange disease, we were shocked to learn that it was Ebola," Byaruhanga said. "Our only hope is that in the past when Ebola broke out in other parts of Uganda it was controlled."

The challenge, he said, was retaining the services of all the nurses and doctors who are being asked to risk their lives in order to look after the sick.

"Their lives are at stake," he said.

Officials also worry that other villagers suffering from other diseases might be afraid to visit the hospital for fear of catching Ebola, he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-07-28-Uganda-Ebola%20Outbreak/id-7262b484af724f809c4dd330fa90ff6f

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Saturday, July 28, 2012

Gulp More Liquid ? The benefits of using Hypnotherapy out to Stay ...

This article has been viewed 22 times.

Gulp more water. A trouble-free enough injunction, but still individuals who are repeatedly disregard its life-size affects health and fitness, emotional joy, weight reduction, in addition to weight prevention. Liquid makes up 70% of your respective system?s heap. Your blood is similar to a river that is actually packages through your body system, carrying needed o2 to every chamber. It can be similar to just how the Nile brought wares and fields to the facebook users of Egypt.

How did the culture of Egypt get to survive for millenia? Only on account of the regular surge of the existing all-powerful Nile. Yet still, the general drink you are going to drink today?especially if that infusion contains spirits, like keg or wine?is only going to dry the customer. Nowadays it?s a challenge to acquire the quantity of water you really want to go on and increase. Fortunately, self hypnosis may help.

H2O Everywhere

Much of your regular system are created out of water. Superb old dihydrogen monoxide (H2O) gets oxygen directly into receptors of your whole body. It assists the cellular matrixes within your body system change over carbohydrates and o2 straight into the fuel you need to shift and think. Ultimately, it gets carbon monoxide waste materials away from your panels and away from your body system. Ocean purifies your whole body and detoxes it of waste, which might otherwise cause sicknesses.

Have you been Our Enough?

To operate properly, you have to be our about 13 foods of fluids whilst visiting a man. Women will need to eat around 11 foods day-by-day. The irony is, with the various liquids we?ve out there to the world now, it?s simple to actually overlook the fact that the foremost key swill of every. Once we attend a diners or have a dinner, we?re preconditioned to desire sickly refreshments like soda pop.

If we?re ?out on the locality,? our company consume keg or other spirits. Instead of going in the direction of our day-to-day the water restriction, each of these beverage only function to dehydrate the world. It is simple to don?t remember our health the minute we?re out with this neighbors.

All Unsweetened dried Up Inside

So what happens if you overlook that canal coursing inside of your body, if you do drown that is actually canal in keg and disregard out to reinvigorate perhaps one of the major components of your old material frame? You?ll certainly get dry. You?ll certainly get tired. You?ll certainly think more steadily, so you might not even have any idea for what reason. You?ll certainly reduce the strength to do your exercise routine, adverse any has at weight loss you may experience been making. All of a sudden, you?ll often find ones self in solid need for burning fat help. Plus, your immunity system will be impaired.

Take More Liquid Which have Subliminals

To summary it, your health is all-too-easy to actually ignore. That?s why you will find self-hypnosis. Which have self-hypnosis, you will train of your unwitting thoughts to want precisely what your body needs. After a period of normal classes, you?ll find your true self desiring the real ?elixir of life style,? every day?without even thinking about it. Uncover brilliant health and fitness by managing the simple capability of hypnotherapy out to drink more liquid.

The author likes writing about various topics. Find out more about watch The Lorax netflix and watch The Hunger Games movie online on megavideo here.

Source: http://www.article-i.com/women-only/female-health-issues/gulp-more-liquid-the-benefits-of-using-hypnotherapy-out-to-stay-hydrated-aptly/

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reignfans.com The Best Source to Cash Your Structured Settlements

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Source: http://www.reignfans.com/the-best-source-to-cash-your-structured-settlements.html

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Adaptive Sports and Recreation Breakdown - blog*spot

The goal of the "Breakdown" is to feature the best of the web from the recent past as it relates to adaptive sports competitions, Paralympic information, disability sport, videos, news, information and more.

For submissions of video, sports reporting, articles, pictures and anything adaptive sports news worthy please send submissions for consideration to adaptivesportandrecreation@gmail.com

Competition Results:

National Junior Disability Championships:

The National Junior Disability Championships took place this week in Mesa Arizona, USA. This annual event is hosted by Wheelchair and Ambulatory Sports USA and the 2012 local partner Arizona Disabled Sports?. Youth from all over the world attend to compete in athletics, archery, power lifting, swimming, table tennis and more.

British Open Wheelchair Tennis Championship:?

Dutchwoman Esther Vergeer have not been beaten in wheelchair tennis is 9 years. She claimed her 12th British Open Wheelchair Tennis Championship title this week.

What is Goalball?

Canada has the win in Goalball! (includes video)

Canada beats Japan to win the fourth International Goal Ball Classic in Alabama. This exciting sport is a blast to play, highly competitive and all spectators need to keep extra quite so the player can hear the bells in the ball.

Paralympics:

London 2012 Smart Phone App:

The official London 2012 App for Smart Phones has been released for the Olympic and the Paralympics. ?This app was designed with the sports fan in mind and includes useful information on venues, schedules, scores and more. ?

Everything you need to know about the Paralympics, but were afraid to ask

The UK newspaper the Guardian has published a short article answering some hot questions about the Paralympics that some people might be afraid to ask. Where did the name Paralympics come from? How hard do Paralympians train? How should I behave around Paralympians? Find answers to these questions.

Channel 4 "Meet the Super Humans" commercial makes a big impression (includes video)

Channel 4 has a good thing going. ?They created a TV spot called "Meet the Super Humans"?about the 2012 British Paralmypic Team?that has gone viral on the Internet. ?This is a short article about the making of the piece which includes a high definition clip of the ad. ?Watch it once and you will have to watch it again.

Wheelchair Rugby (AKA Murderball) schedule for London 2012

The International Paralympic Committee has released the schedule for the London 2012 Wheelchair Rugby Match ups. The tickets are scarce so plan on watching this on TV and tell your friends.

Eye Candy:

Erik Weihenmayer, the first person with a visual impairment?

to climb the seven summits runs class 3 white water

Challenged Athletes Foundation interview (includes video)

Blake Leeper, who is sponsored by the Challenged Athletes Foundation?, is on his way to the London 2012 Paralympics. The Fox 5 news team interviews him.

Ce-Ce Mazyck, a wounded warrior, introduces us to?

the art and technique of javelin?

South Sudanese Wheelchair Basket Ball Team

These individuals have over come the ravages of war in a developing national. ?The wheelchair basketball team from South Sudan is hoping for a Paralympic berth.

Nike: Find your Greatness

Features some adaptive athletes

Humans:

Oksana Masters posing in the Bodies Issue of ESPN magazine

Individuals at the top of their game, fit, toned and naked. Each year ESPN releases the Bodies Issue and it always causes a stir. This year was no exception. Oksana Masters, a Paralympic rower is featured in her birthday suit. You be the judge.

Athletes Prosthetic Arm Stolen


Arnaud Assoumani, who one a gold medal in Beijing 2008, has gotten his gold arm back. ?French police saved the day when they returned it after thieves stole it.
Alana Nichols on "Qualified"
First athlete to win a gold medal in the both
the Summer and Winter Paralympics
(Check out the "Gun Rack" at the end)

Hang gliding...good clean fun


Hang gliding is a sport not for the faith of heart. This activity does have it's risks but it also has the reward of soaring like a bird. These individual are stepping up and leaving their disability on the ground.

Education:


Adaptive Archery (includes video)

This very blog "Adaptive Sport and Recreation" published an informative post this week on Adaptive Archery for persons with disabilities. This great pastime can be enjoyed as a recreation or as competition. It sure is making the headlines these days.

Adapt2Achieve Conference

Disabled Sports USA is hosting their Adapt2Achieve Conference in Seattle Washington on August 19-21. Developed with the adaptive sports program in mind this conference will feature train sessions in adaptive archery (see above), adaptive climbing, and nonprofit administrative topics. ?CEUs will be offered from ATRA. ?Register today!
??

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The Adaptive Sport "Breakdown" is meant to be shared. Please take a moment and post in social media. As well please leave a comment below on how we can make this update better in the future.?

Thanks for tuning in.

Knowledge is Empowerment!
-RAM

Source: http://adaptivesportandrecreation.blogspot.com/2012/07/adaptive-sports-and-recreation.html

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Friday, July 27, 2012

What are some ways to co-parent after a divorce? | Dallas Divorce ...

Ask any parent, and they will tell you that raising a child comes with challenges. But how about co-parenting a child with an ex-spouse? That has its own challenges, particularly if one or both spouses is unable to let go of hard feelings.

There are ways to co-parent successfully after a divorce. While they may take some practice and patience, what matters in the end is if the child gets what they need without feeling torn between the parents. Here are some ideas.

? Check in regularly with the other parent. This may be easier said than done for some parents. Whether it's a brief phone conversation, a detailed email or an in-person meeting, communicating with the other parent is extremely important. This is the time when expectations can be set and calendars can be filled in.

? Don't get in the way of a child's relationship with the other parent. Speaking negatively of your ex-spouse or trying to interfere with their relationship with the child will likely backfire. It's important for children to have healthy relationships with both parents.

? Treat former in-laws with respect. They are often caught in the middle after a divorce. Kids benefit from seeing their grandparents, and cutting them out of the family picture will only serve to make everyone upset. They should get time with the children, too.

? Respect the other parent's rules and boundaries. You may not agree with everything the other parent does regarding the children, but unless it is something dangerous, it's often best to step back and let them parent how they want. Criticizing them will likely only strain the relationship further.

Source: Huffington Post, "Make smart choices for post-divorce co-parenting success," Rosalind Sedacca, July 23, 2012

Source: http://www.lisamcknight.com/blog/2012/07/what-are-some-ways-to-co-parent-after-a-divorce.shtml

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The Top 50 Sources Where Wikipedia Gets Its Facts [Wikipedia]

You didn't think Wikipedia was all original content, did you? According to Webempires, the online encyclopedia cites and references over two million different websites. You can find the entire exhaustive list here if you've got a couple of weeks to spare, or check out this handy infographic which highlights just the top 50 sources. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/v0sCQDzl3os/the-top-50-sources-where-wikipedia-gets-its-facts

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22 Health and Fitness Resources You May Have Missed | Greatist

This week, our CEO and founder finished up his 6 week Absperiment ? wheeew ? just in time to find out what?s really?in his hot dog. The Greatist Team hit the outdoor playground for some sweat-inducing circuits, and learned how pros like Holley Mangold and Curtis Williams tackle training sessions. With it being social wellness month and all, come on, get hap-PY! Hit up the nearest food truck (so long as it made our list of the healthiest ones cruising across the states), and get a newfangled caffeine kick with one of our unexpected reasons to love the stuff! ? Nicole McDermott

Health
Chia Seeds

Photo by Jordan Shakeshaft

The 26 Healthiest Food Trucks in America
While we only wish we could head out on a food truck road trip to try all of these healthy, innovative meals on wheels, we compiled a list instead. Here are the 26 healthiest food trucks cruising around the good ol? U.S. of A.

Atlanta Bans Public Cigarette Smoking. Will it Make Us Healthier?
Atlanta recently banned smoking in public parks. Is the ban an effective way to keep parks clean, or is it doing little more than ostracizing smokers?

Recipe: Pan-Seared Fish Tacos
These fresh fish tacos are perfect for a hot summer night. The flavors of the fish with the peaches, cilantro, and avocado brighten up any dinner table.

14 Tips to Get Happy for Social Wellness Month
July is Social Wellness month, and what better way to celebrate than with 14 fun, healthy tips? So take a read and put a smile on that face.

15 Unexpected Reasons to Love Caffeine
The best part of waking up? is realizing that morning caffeine jolt can actually be good for our health. Here are our 15 favorite articles on coffee, tea, and everything else caffeinated. Grab a mug and enjoy!

Superfood: Chia
Funny hairdos aren?t all chia?s good for. Ch-ch-ch-choose these little black seeds for protein, calcium, antioxidants, and a whole bunch of other vitamins and minerals.

Links We Love: The Strongest 10-Year-Old in the World (and More)
Ready for some weekend link-love? From why weird experiences boost our creativity to a 99 pound powerlifter, we?ve found our favorite links from around the web.

Joey Chesnut on How to Eat 60 Hot Dogs in 10 Minutes
It?s National Hot Dog Day, so while you?re taking a cheat day by eating one, why not learn how the best competitive hot dog eater scarfs these tubular treats?

What?s Really in My Hot Dog
Happy National Hot Dog Day! To celebrate, we decided to uncover what?s?really?in those dogs and give you some, erm, better alternatives.

Recipe: Cauliflower Crust Pizza
Mix up the pizza game with this interesting take on a classic italian dish that uses grated cauliflower as the crust. Buono appetite!

Fitness

The 25 Most Inspiring Olympic Moments of All Time
With the London 2012 Summer Olympics just one day away, what better time to celebrate the most awe-inspiring moments seen on the world stage? Here are Greatist?s picks.

Are Hot Workouts Safe?

With all the hot workout hype, should you take your fitness to the Sahara or take a chill pill instead? Read on to see if turning up the heat can really do a body good.

Does Carb Loading Really Work?
Pre-race pasta parties sure sound like a fun way to enjoy the night before the race. But does carb loading really work, and how can we use it to achieve peak performance?

Six-Pack Abs in Six Weeks #Absperiment: It?s Over
Greatist?s founder went on a six-pack abs in six weeks challenge, and he?s ready for his big reveal. Read on to see how he did (slideshow included!).

The Best #imagreatist Fitness Tips
Power walking, strength training, century rides? Half marathons, interval training, yoga? What else? Here are our favorite fitness tips and feats of the week, brought to you by the Greatist community.

Live Like a Pro: Olympic Weightlifter Holley Mangold
She?s one of the strongest women in the world with a pedigree to back it up. Learn more from weightlifting phenom Holley Mangold as she prepares for the 2012 Games.

We Did It: East River Park Outdoor Gym
This past week, The Greatist Team headed over to East River Park in NYC to test out the track and outdoor gym.

In the Gym with Curtis Williams, NFL Pro-Turned-Trainer
Ready to train like a pro ? a former NFL pro? Yeah, us too. Read on for an inside look at NYC trainer Curtis Williams ? exclusive speed and agility workout included!

Happiness

Is it OK to Have a Fetish?
Sneezes, feet, and armpit hair. Some people take it to the extreme in the bedroom, but is there anything wrong with having a fetish?

Do You Believe in Magic? Interview with Matthew Hutson
From unlucky black cats to energy healing, superstition plays a huge role in human life. We asked Matthew Hutson, author of The 7 Laws of Magical Thinking, to tell us why.

Are You Sabotaging Your Sleep?
With life?s stressors waiting around every turn, it?s tough to get enough quality sleep. Here are four ways to keep those problems at bay and get some good ole shuteye.

Source: http://greatist.com/health/health-fitness-resources-072712/

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Thursday, July 26, 2012

5 Strategies to Incorporate Network Advertising and marketing ...

Many people are seeking to get a new enterprise opportunity to create money at property. The net has produced it attainable to market place goods and services around the globe. This has produced an enormous potential for folks to become involved in their very own house company.

Many people perform at residence for themselves, providing services to other people, or promoting their own exclusive items. You will find business possibilities in MLM, and network marketing that allow a person to earn money even though promoting for an individual else. Either way, it depends upon the ambition and dedication in the individual involved. Any organization can become a success with challenging function as well as an item that is effortless to sell.

Obtaining a Company Chance

Network advertising and marketing is about selling and dispersal. You would like to have your product identified to potential customers and have it distributed to ensure that it creates a lot more sales for you. By investing a tiny sum of money, it is possible to start to create income and work from property selling your own items or products for yet another business.

Promote Your business

The very first and finest form of marketing and advertising is word of mouth. Anytime someone finds a brand new product, or perhaps a new store, new physician, or possibly a new restaurant, they inform every person they know about it. This stirs up interest and encourages people to try some thing new. When you have a product or service to sell, the ones who use it?s going to turn into your best kind of advertisement. A lot of corporations depend on this good type of network marketing.

Secondly, to produce your item identified to a lot more people, try printing enterprise cards to hand out everywhere you go. When you go to the grocery shop, church, school meetings or other daily places, hand your cards out having a friendly smile. This can spread your name and enhance your business chance.

Thirdly, it is possible to promote your goods by means of your personal internet site or by emailing people from associated websites. The web is also beneficial for advertising by submitting articles connected to your items to other sites.

Fourthly, yet another powerful network marketing tool is really a send-out card. These preserve you in touch along with your clientele and clients by using a far more private method. Sending an e-mail is simple and cheap nevertheless it doesn?t seem as individual as a card addressed to them

Fifthly, network advertising isn?t just about making an one-time sale. You have to create new sales and hold your clients coming back for repeat company. An enterprise opportunity that enables you to add goods or sell a number of goods for your preceding consumers will give you a solid foundation for creating a steady yearly revenue.

Following up on your consumers will create a relationship which will develop confidence within your property business. By thanking your consumers for their business and staying in touch, you show them how beneficial their business would be to you.

Construct Your house Company

The achievement of one?s residence business will rely in your dedication and hard operate. You don?t need to commence out using a large amount of overhead expenses and massive facilities. By investing a couple of hours per week, you can slowly construct your company and not be overwhelmed by debt. Start working today to create up your property enterprise and take pleasure in fulfillment and economic security.

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Source: http://pyaardosti.com/5-strategies-to-incorporate-network-advertising-and-marketing-together-with-your-home-based-business-chance

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Superstitions of Indonesia

In this report we present a compendium of localized ?superstitions? in Indonesia regarding each day life & the meanings of the omens of Nature.

Avoid brushing the home at nighttime as this would make it hard to draw in luck.

Avoid sewing a push on your shirt although wearing it as this would reason a serious sickness not long after that would last for about a calendar & you woud all of the time fail in your efforts in making a living.

Avoid combimg your pilus although walking as you will find youself in an embarassing situation.

Avoid being in the bathe too long as this would make your face seem old.

Avoid taking a bathe or shower during good hours as this would accelerate the aging process.

An unmarried lady ought nullify laundering her pilus on a Saturday as this would reason her to marry a man hard to please.

If you come crosswise a piece of cayene chili pepper in a pan for no apparent reason, this is a omen that a disaster is about to occur.

If someone prepares a food that is too salty, this is a omen that the person is in cherish & wishings to marry.

Avoid consuming rice from a little plate as this would reason your close relations to spurn you.

Avoid consuming from the niche of a desk as this would reason troubles with the in-laws & your spousal kinship will be in a wreck.

Avoid consuming in front of the doorway as this would reason one misfortune in detecting a spousal kinship partner.

Children ought nullify moving locations at the desk during a food as this would reason them to have a step-father or mother.

Children ought consume a lot of hen wings whenever they need to eventually travel to overseas.

If you have a bad belief when you are about to go away the house?then don?t! As this is a omen that anything disastrous might occur although out.

Avoid construction a home facing northerly as this would reason the possessor to fail to win riches.

Avoid construction a home facing an open arena as this would reason the possessor to become spendrift.

Avoid construction a kitchen facing the front doorway as this would reason sorrows & sufferings since of money.

Avoid construction a garage at the back of the home as this would all of the time reason unfortunate circumstances.

Avoid construction a wall fence as high as 2-3 metres around the home as this would reason bankrupcy & to be stranded by one?s job partners.

Avoid construction a pond inside the home as this would reason bad luck & the appendages of the fellowship will alternately be stricken with illnesses.

Avoid construction a home with no back doorway as the dwellers will all of the time be physically ill.

While moving home it is suggested to take by many dirt from the garden of the ancient home & sprinkle it in the vicinity of the new so as to endure the harmony established.

Avoid scratching one?s head although being sexually intimate as this would result in bad luck & slander from people.

Avoid appearing at the intimate organs of your spouse although sex as this would result in bad luck for a week.

Avoid sex commencing from the seventh-month pregnency as this would reason the baby to be adulterous & disrespectful towards the parents.

Avoid slaughtering an animal when your wife is pregnent as this would reason the baby to be born with a scar on its neck.

Avoid hunting or torturing an animal when your wife is pregnent as this would reason your baby to resemble the animal.

Avoid disliking someone intensely although pregnent as this would reason your baby to adopt the characteristics of the disliked person.

Avoid mocking at a handicapped person during pregnency as this would reason your baby to be born disabled.

Avoid keeping a spoon with the salt repository during pregnency as this would reason difficulties during labor.

Avoid standing at the front doorway in the evenings during pregnancy as this would reason negative spirits to attempt the fetus.

Avoid wearing earings commencing from the 3rd calendar of pregnency as this would reason you to ambition of being intimate with your husband whereas in reality it is an incubus impersonating him.

A man ought nullify consuming although lying down as this would reason his wife to have difficulties during labor.

It is unfortunate whenever a client suddenly supplies birth in your home as this causes bad luck. It is suggested to move home quickly.

It is suggested to open the doors & windows of your home so that your wife will supply birth without complications.

It is suggested to entomb the placenta of the new-born baby somwhere in the ground at the backdoor of the home so that the baby will never be in want.

It is suggested to drink coco water during the latter stage of pregnancy so that the baby will be born fair-minded of face.

It is suggested not to seem at a coffin when it is being lowered into the ground as this might result in a serious illness.

It is suggested not to seem at a coffin being shut & nailed as this might reason bad luck for a year.

It isa suggested to wash one?s face after escorting a coffin to its grave so as to nullify being followed by the ghost of the deceased.

If a lamp goes off in a room wherever the deceased is kept prior to burial, indicates that different appendage of the fellowship will shortly face death.

It isa suggested for a pregnant mom to seem at pretty pictures so that her baby would be born pretty as well.

It is suggested for a pregnant mom not to be unhappy during pregnancy as this would reason the baby to be born to become a whiner.

Avoid habitually nipping the lower lip as this causes bad luck.

Avoid habitually nipping the upper lip as this would reason tons of monetary debts in life.

Avoid pretending to shout as this would reason one?s parents to be quickly deceased.

Avoid mistreating one?s daughter as this would reason her to be mistreated later on by her husband.

Avoid singing or whistling although at a food as this causes failures in one?s endeavours.

Avoid baffling one?s daughter at her buttocks as this would reason her later on to become sexually hyperactive & would reason practically national problems.

Avoid making defrayals at nighttime as this would result in bad luck & bankrupcy.

Women ought nullify pulling the hairs of their eyebrows as this would result in frgidity & misfortune in acquiring intimate satisfaction.

Avoid tidying the ears at nighttime as this would result in bad luck.

One ought nullify whistling often in one?s home as this would draw in negative entities.

One ought nullify handing handkerchiefs to one?s devotee as this would result in a burst in the relationship.

Avoid taking pictures with odd-numbers of folks present as this would result in the quick decease of one of them.

Avoid beginning umbrellas in the home as this would result in difficulties in life.

Avoid wiping one?s face with a shirt as this would result in the indifference of others towards oneself.

Avoid appearing at onseself in the mirror too often as this would result in others being tired & repulsed with one.

Avoid peeping at others bathing as this would reason one?s eyes to swell.

Avoid consuming a food earlier the elders have done so as this would result in bad luck.

Avoid slicing one?s pilus in one?s home at nighttime as this would draw in negative entities that would seem in one?s dreams.

Avoid wearing blooad or light-green swimwear at sands as this would result in the wearer getting a bride or groom to spirit entities (incubus, succubus).

Avoid shouting or utilising vulgar words although in the forest or wilderness as this would reason oneself to be possessed by negative entities.

If you begin menstruating on a Sunday you will contact an ancient friend.

If you begin menstruating on a Monday you will shortly win luck.

If you begin menstruating on a Tuesday you will shortly be enjoying yourself in the following days.

If you begin menstruating on a Wednesday you will shortly clank with someone.

If you begin menstruating on a Thursday you will shortly undergo unfortunate incidents & be in practically sorrow.

If you begin menstruating on a Friday you will shortly have fun.

If you begin menstruating on a Saturday you will shortly have a enjoyable surprise.

If a hound howls at midnight signifies a travel to from ancestral spirits.

If a hound howls as although weeping at midnight signifies decease in the family

If a hound howls recent midnight signifies a wandering pedestrian spirit in the premises.

It is stated that the blood of a pitch-black hound is competent of exorcising possessing spirits.

It is suggested for pregnant women to spot a match of scissors underneath the pillow although napoing to protect against psychic attempt & pitch-black magick.

Avoid urinating at the foot of huge trees as this would inflame the tree-spirits & reason them to possess oneself.

Avoid keeping the junk or dirt from a grave as this would reason the spirit corresponding to the grave to haunt the spot wherever the dirt is kept.

Placing blooad onions, chillis & turmeric in a purse & hung above the front doorway protects the home & fellowship against pitch-black magick & negative entities.

If a cat licks one?s foot signifies that someone close to us will win a windfall within one month.
If a sparrow finds its path in one?s home signifies a spousal kinship in one?s family.

If a butterfly finds its path in one?shome signifies a travel to from an significant visitor.

Avoid handing a cat a bathe as this would result in storms & hurricanes.

Carry the rare hollowless piece of bamboo to ward-off pitch-black magick.

It is suggested to say one?s wishings during a falling star so that it would come true.

It is suggested to swim in a lake during enitre moon as this would reason one to become extremely attractive.

It is suggested to nap on the far side midnight to nullify psychic attacks.

It is suggested to nap on the flooring to nullify psychic attacks.

It is suggested to keep sacred objects in the home to protect one?s family.

Copyright 2006 Luxamore

No related posts.

Source: http://www.society-guide.com/superstitions-of-indonesia/

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Small business How Web Design Can Enable Your Small business ...

Small business How Web Design Can Enable Your Small business

When you go into Enterprise for the initially time, one particular of the most significant points you can do in terms of marketing your Organization and giving people today a spot to come across details is to have a site created. It does not matter what kind of business you are in; you can most likely locate a way to make a internet site function in your favor and present the sorts of data that possible consumers may well be searching for. Right here are a couple of examples of how a web site can advantage your Organization and Aid you connect with these who may possibly be interested in the item or service you happen to be providing.

For buyers who are currently familiar with your Company but may want info on some of the a lot more certain data ? for instance, the address to exactly where your store or shop is situated, or what your hours of operation are ? a internet site can be a incredibly valuable tool. Constructing a internet site for a restaurant can also give you an chance to show off your menu, as effectively as a handful of photographs of some of the dishes you are capable of preparing. For an individual who?s hungry, a photo of a mouth-watering key course can be incredibly the motivator in terms of restaurant choice.

A single of the most potent strategies of have a web page developed for your Enterprise is the way it can Support you attract the prospective clients who have under no circumstances heard of your Organization ahead of. By staking your claim and Constructing up your personal property on the Internet, you can give these who use search engines like Google, Bing, or Yahoo! a way to uncover you if they are otherwise unfamiliar with your Organization. For instance, if you run a pizza store in your city and an individual searches working with the term ?pizza retailer? plus the name of your city, obtaining a web site will allow you to show up in search final results for that term, which can potentially bring you far more Small business.

If you happen to be prepared to create a web page for your Company, it is typically a excellent concept to perform with an skilled Web Design Organization. Working with services that Support you automatically create a web page can Assist you get a page up onto the Net, but oftentimes, those pages will appear just like thousands of other pages, and will not be optimized to Aid you be as visible in search engine final results. A Web Design Business can tailor your website to your specifications, give it a skilled-seeking Style that stands out from your competitors, and optimize your web page so that buyers who are searching for organizations in your market can uncover you much more simply.

Those are just a couple of strategies that Web Design can Support your Organization. To discover a respected Web Design Enterprise in your location, function an Web search, or speak with other organizations to see which firms they?ve been impressed with.

No related posts.

Source: http://www.tekneadesign.com/small-business-how-web-design-can-enable-your-small-business/

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Chemical makes blind mice see; compound holds promise for treating humans

ScienceDaily (July 25, 2012) ? A team of University of California, Berkeley, scientists in collaboration with researchers at the University of Munich and University of Washington, in Seattle, has discovered a chemical that temporarily restores some vision to blind mice, and is working on an improved compound that may someday allow people with degenerative blindness to see again.

The approach could eventually help those with retinitis pigmentosa, a genetic disease that is the most common inherited form of blindness, as well as age-related macular degeneration, the most common cause of acquired blindness in the developed world. In both diseases, the light sensitive cells in the retina -- the rods and cones -- die, leaving the eye without functional photoreceptors.

The chemical, called AAQ, acts by making the remaining, normally "blind" cells in the retina sensitive to light, said lead researcher Richard Kramer, UC Berkeley professor of molecular and cell biology. AAQ is a photoswitch that binds to protein ion channels on the surface of retinal cells. When switched on by light, AAQ alters the flow of ions through the channels and activates these neurons much the way rods and cones are activated by light.

"This is similar to the way local anesthetics work: they embed themselves in ion channels and stick around for a long time, so that you stay numb for a long time," Kramer said. "Our molecule is different in that it's light sensitive, so you can turn it on and off and turn on or off neural activity."

Because the chemical eventually wears off, it may offer a safer alternative to other experimental approaches for restoring sight, such as gene or stem cell therapies, which permanently change the retina. It is also less invasive than implanting light-sensitive electronic chips in the eye.

"The advantage of this approach is that it is a simple chemical, which means that you can change the dosage, you can use it in combination with other therapies, or you can discontinue the therapy if you don't like the results. As improved chemicals become available, you could offer them to patients. You can't do that when you surgically implant a chip or after you genetically modify somebody," Kramer said.

"This is a major advance in the field of vision restoration," said co-author Dr. Russell Van Gelder, an ophthalmologist and chair of the Department of Ophthalmology at the University of Washington, Seattle.

Kramer, Van Gelder, chemist Dirk Trauner and their colleagues at UC Berkeley, the University of Washington, Seattle, and the University of Munich will publish their findings on July 26, in the journal Neuron.

The blind mice in the experiment had genetic mutations that made their rods and cones die within months of birth and inactivated other photopigments in the eye. After injecting very small amounts of AAQ into the eyes of the blind mice, Kramer and his colleagues confirmed that they had restored light sensitivity because the mice's pupils contracted in bright light, and the mice showed light avoidance, a typical rodent behavior impossible without the animals being able to see some light. Kramer is hoping to conduct more sophisticated vision tests in rodents injected with the next generation of the compound.

"The photoswitch approach offers real hope to patients with retinal degeneration," Van Gelder said. "We still need to show that these compounds are safe and will work in people the way they work in mice, but these results demonstrate that this class of compound restores light sensitivity to retinas blind from genetic disease."

From optogenetics to implanted chips

The current technologies being evaluated for restoring sight to people whose rods and cones have died include injection of stem cells to regenerate the rods and cones; "optogenetics," that is, gene therapy to insert a photoreceptor gene into blind neurons to make them sensitive to light; and installation of electronic prosthetic devices, such as a small light-sensitive retinal chip with electrodes that stimulate blind neurons. Several dozen people already have retinal implants and have had rudimentary, low vision restored, Kramer said.

Eight years ago, Kramer, Trauner, a former UC Berkeley chemist now at the University of Munich, and their colleagues developed an optogenetic technique to chemically alter potassium ion channels in blind neurons so that a photoswitch could latch on. Potassium channels normally open to turn a cell off, but with the attached photoswitch, they were opened when hit by ultraviolet light and closed when hit by green light, thereby activating and deactivating the neurons.

Subsequently, Trauner synthesized AAQ (acrylamide-azobenzene-quaternary ammonium), a photoswitch that attaches to potassium channels without the need to genetically modify the channel. Tests of this compound are reported in the current Neuron paper.

New versions of AAQ now being tested are better, Kramer said. They activate neurons for days rather than hours using blue-green light of moderate intensity, and these photoswitches naturally deactivate in darkness, so that a second color of light is not needed to switch them off.

"This is what we are really excited about," he said.

Coauthors with Kramer, Van Gelder and Trauner are UC Berkeley current or former post-docs or graduate students Aleksandra Polosukhina, Jeffrey Litt, Ivan Tochitsky, Ivan De Kouchkovsky, Tracy Huang and Katharine Borges; and post-doctoral fellow Joseph Nemargut and ophthalmology resident Yivgeny Sychev at the University of Washington.

The work was supported by the National Eye Institute of the National Institutes of Health (EY018957 & EY003176) and Research to Prevent Blindness.

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The above story is reprinted from materials provided by University of California - Berkeley. The original article was written by Robert Sanders.

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Journal Reference:

  1. Aleksandra Polosukhina, Jeffrey Litt, Ivan Tochitsky, Joseph Nemargut, Yivgeny Sychev, Ivan De?Kouchkovsky, Tracy Huang, Katharine Borges, Dirk Trauner, Russell?N. Van?Gelder, Richard?H. Kramer. Photochemical Restoration of Visual Responses in Blind Mice. Neuron, 2012; 75 (2): 271 DOI: 10.1016/j.neuron.2012.05.022

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120725132210.htm

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